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Target
Metabotropic glutamate receptor 3
Ligand
BDBM50523865
Substrate
n/a
Meas. Tech.
ChEMBL_1891255 (CHEMBL4393082)
IC50
>10000±n/a nM
Citation
 Reed, CW; Washecheck, JP; Quitlag, MC; Jenkins, MT; Rodriguez, AL; Engers, DW; Blobaum, AL; Conn, PJ; Niswender, CM; Lindsley, CW Surveying heterocycles as amide bioisosteres within a series of mGlu Bioorg Med Chem Lett 29:1211-1214 (2019) [PubMed]  Article
Target
Name:
Metabotropic glutamate receptor 3
Synonyms:
GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c
Type:
Enzyme Catalytic Domain
Mol. Mass.:
98889.09
Organism:
Homo sapiens (Human)
Description:
metabotropic glutamate 1c 0 HUMAN::Q14832
Residue:
879
Sequence:
MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLHLNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
  
Inhibitor
Name:
BDBM50523865
Synonyms:
CHEMBL4476495
Type:
Small organic molecule
Emp. Form.:
C20H15F3N4O4
Mol. Mass.:
432.3527
SMILES:
COc1ccc(cc1OC)-c1nnc(o1)-c1cc(OC(F)(F)F)ccc1-n1ccnc1
Structure:
Search PDB for entries with ligand similarity: