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Target
Cyclin-dependent kinase 6
Ligand
BDBM50526792
Substrate
n/a
Meas. Tech.
ChEMBL_1901121 (CHEMBL4403343)
IC50
>10000±n/a nM
Citation
 Teng, Y; Lu, K; Zhang, Q; Zhao, L; Huang, Y; Ingarra, AM; Galons, H; Li, T; Cui, S; Yu, P; Oumata, N Recent advances in the development of cyclin-dependent kinase 7 inhibitors. Eur J Med Chem 183:0 (2019) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM50526792
Synonyms:
CHEMBL4454044
Type:
Small organic molecule
Emp. Form.:
C23H33N7O
Mol. Mass.:
423.5544
SMILES:
CC(C)c1cnn2c(NCc3ccccc3N(C)C)nc(OC3CCN(C)CC3)nc12
Structure:
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