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Target
Carbonic anhydrase 4
Ligand
BDBM50528164
Substrate
n/a
Meas. Tech.
ChEMBL_1904503 (CHEMBL4406725)
Ki
860±n/a nM
Citation
 Nocentini, A; Alterio, V; Bua, S; Micheli, L; Esposito, D; Buonanno, M; Bartolucci, G; Osman, SM; ALOthman, ZA; Cirilli, R; Pierini, M; Monti, SM; Di Cesare Mannelli, L; Gratteri, P; Ghelardini, C; De Simone, G; Supuran, CT Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. J Med Chem 63:5185-5200 (2020) [PubMed]  Article
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50528164
Synonyms:
CHEMBL4453128
Type:
Small organic molecule
Emp. Form.:
C18H17N2O4PS
Mol. Mass.:
388.377
SMILES:
NS(=O)(=O)c1ccc(OP(=O)(Nc2ccccc2)c2ccccc2)cc1
Structure:
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