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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50529578
Substrate
n/a
Meas. Tech.
ChEMBL_1908897 (CHEMBL4411255)
IC50
>10000±n/a nM
Citation
 Ernst, G; Akuma, D; Au, V; Buchler, IP; Byers, S; Carr, GV; Defays, S; de León, P; Demaude, T; DePasquale, M; Durieu, V; Huang, Y; Jigorel, E; Kimos, M; Kolobova, A; Montel, F; Moureau, F; Poslusney, M; Swinnen, D; Vandergeten, MC; Van Houtvin, N; Wei, H; White, N; Wood, M; Barrow, JC Synthesis and Evaluation of Bicyclic Hydroxypyridones as Inhibitors of Catechol  ACS Med Chem Lett 10:1573-1578 (2019) [PubMed]  Article
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50529578
Synonyms:
CHEMBL4461693
Type:
Small organic molecule
Emp. Form.:
C15H14Cl2N2O2
Mol. Mass.:
325.19
SMILES:
Oc1cn2CCN(Cc3ccc(Cl)cc3Cl)Cc2cc1=O
Structure:
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