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Target
D(2) dopamine receptor
Ligand
BDBM50530687
Substrate
n/a
Meas. Tech.
ChEMBL_1913690 (CHEMBL4416273)
Kd
3.4±n/a nM
Citation
 Fyfe, TJ; Kellam, B; Sykes, DA; Capuano, B; Scammells, PJ; Lane, JR; Charlton, SJ; Mistry, SN Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D J Med Chem 62:9488-9520 (2019) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Human
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50530687
Synonyms:
CHEMBL4472585
Type:
Small organic molecule
Emp. Form.:
C21H23Cl2NO2
Mol. Mass.:
392.319
SMILES:
OC1(CCN(CCCC(=O)c2ccccc2Cl)CC1)c1ccc(Cl)cc1
Structure:
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