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Target
Methionine aminopeptidase 1
Ligand
BDBM401275
Substrate
n/a
Meas. Tech.
ChEMBL_1914457 (CHEMBL4417040)
IC50
>10000±n/a nM
Citation
 Heinrich, T; Seenisamy, J; Becker, F; Blume, B; Bomke, J; Dietz, M; Eckert, U; Friese-Hamim, M; Gunera, J; Hansen, K; Leuthner, B; Musil, D; Pfalzgraf, J; Rohdich, F; Siegl, C; Spuck, D; Wegener, A; Zenke, FT Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor  J Med Chem 62:11119-11134 (2019) [PubMed]  Article
Target
Name:
Methionine aminopeptidase 1
Synonyms:
Aminopeptidase | KIAA0094 | MAP 1 | MAP11_HUMAN | METAP1 | MetAP 1 | Methionine Aminopeptidase Type 1 (MetAP1) | Peptidase M 1
Type:
Enzyme
Mol. Mass.:
43220.79
Organism:
Homo sapiens (Human)
Description:
MetAP1 with an N-terminal six histidine tag was expressed in baculovirus infected sf9 cells.
Residue:
386
Sequence:
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
  
Inhibitor
Name:
BDBM401275
Synonyms:
US10005756, Compound A40
Type:
Small organic molecule
Emp. Form.:
C24H25ClFN5O4
Mol. Mass.:
501.938
SMILES:
NCCCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Structure:
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