Reaction Details  Report a problem with these data
Target
Methionine aminopeptidase 2
Ligand
BDBM401275
Substrate
n/a
Meas. Tech.
ChEMBL_1914456 (CHEMBL4417039)
IC50
200±n/a nM
Citation
 Heinrich, T; Seenisamy, J; Becker, F; Blume, B; Bomke, J; Dietz, M; Eckert, U; Friese-Hamim, M; Gunera, J; Hansen, K; Leuthner, B; Musil, D; Pfalzgraf, J; Rohdich, F; Siegl, C; Spuck, D; Wegener, A; Zenke, FT Identification of Methionine Aminopeptidase-2 (MetAP-2) Inhibitor  J Med Chem 62:11119-11134 (2019) [PubMed]  Article
Target
Name:
Methionine aminopeptidase 2
Synonyms:
Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MAP2_HUMAN | METAP2 | MNPEP | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | P67EIF2 | Peptidase M 2 | p67
Type:
Enzyme
Mol. Mass.:
52884.45
Organism:
Homo sapiens (Human)
Description:
P50579
Residue:
478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKESGASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPICDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVRKYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTTVLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDVGEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEVYAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWLDRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
  
Inhibitor
Name:
BDBM401275
Synonyms:
US10005756, Compound A40
Type:
Small organic molecule
Emp. Form.:
C24H25ClFN5O4
Mol. Mass.:
501.938
SMILES:
NCCCNC(=O)c1cc2cc(ccc2[nH]1)N1CC[C@](O)(C(=O)NCc2cc(F)cc(Cl)c2)C1=O |r|
Structure:
Search PDB for entries with ligand similarity: