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Target
Mu-type opioid receptor
Ligand
BDBM50090098
Substrate
n/a
Meas. Tech.
ChEMBL_148861 (CHEMBL756657)
Ki
876±n/a nM
Citation
 Stevens, WC; Jones, RM; Subramanian, G; Metzger, TG; Ferguson, DM; Portoghese, PS Potent and selective indolomorphinan antagonists of the kappa-opioid receptor. J Med Chem 43:2759-69 (2000) [PubMed]
Target
Name:
Mu-type opioid receptor
Synonyms:
MOR-1 | MUOR1 | Mu-type opioid receptor (MOR) | OPIATE Mu | OPRM_RAT | Opiate non-selective | Opioid receptor B | Oprm1 | Ror-b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44503.11
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the mu opioid receptor.
Residue:
398
Sequence:
MDSSTGPGNTSDCSDPLAQASCSPAPGSWLNLSHVDGNQSDPCGLNRTGLGGNDSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSTRVRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50090098
Synonyms:
6,7-Dihydro-4,5alpha-epoxy-5'-guanidinyl-17-methyl-3,14-dihydroxyindolo[2',3':6,7]morphinan | CHEMBL96273
Type:
Small organic molecule
Emp. Form.:
C24H25N5O3
Mol. Mass.:
431.487
SMILES:
CN1CC[C@@]23[C@H]4Oc5c2c(CC1[C@]3(O)Cc1c4[nH]c2ccc(cc12)N=C(N)N)ccc5O |wU:12.15,wD:4.8,5.5,TLB:28:9:12:1.3.2,7:8:12:1.3.2,(9.49,-.92,;8.17,-1.7,;7.47,-2.74,;7.17,-5.5,;8,-6.81,;8.74,-8.16,;7.29,-8.95,;5.68,-8.14,;6.48,-6.81,;5.72,-5.46,;6.5,-4.13,;8.17,-4.15,;8.79,-5.5,;9.57,-4.16,;10.33,-5.53,;11.08,-6.88,;10.28,-8.19,;11.28,-9.35,;12.7,-8.75,;14.08,-9.4,;15.33,-8.53,;15.19,-6.98,;13.81,-6.36,;12.56,-7.23,;16.46,-6.11,;17.87,-6.76,;19.12,-5.87,;17.99,-8.3,;4.18,-5.43,;3.36,-6.77,;4.14,-8.12,;3.03,-9.2,)|
Structure:
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