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Target
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Ligand
BDBM36388
Substrate
n/a
Meas. Tech.
ChEMBL_1929751 (CHEMBL4432927)
Kd
94300±n/a nM
Citation
 Srinivasan, B; Zhou, H; Mitra, S; Skolnick, J Novel small molecule binders of human N-glycanase 1, a key player in the endoplasmic reticulum associated degradation pathway. Bioorg Med Chem 24:4750-4758 (2016) [PubMed]  Article
Target
Name:
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
Synonyms:
3.5.1.52 | N-glycanase 1 | NGLY1 | NGLY1_HUMAN | PNG1 | PNGase | Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase | Peptide:N-glycanase | hPNGase
Type:
PROTEIN
Mol. Mass.:
74392.79
Organism:
Homo sapiens
Description:
ChEMBL_119179
Residue:
654
Sequence:
MAAAALGSSSGSASPAVAELCQNTPETFLEASKLLLTYADNILRNPNDEKYRSIRIGNTAFSTRLLPVRGAVECLFEMGFEEGETHLIFPKKASVEQLQKIRDLIAIERSSRLDGSNKSHKVKSSQQPAASTQLPTTPSSNPSGLNQHTRNRQGQSSDPPSASTVAADSAILEVLQSNIQHVLVYENPALQEKALACIPVQELKRKSQEKLSRARKLDKGINISDEDFLLLELLHWFKEEFFHWVNNVLCSKCGGQTRSRDRSLLPSDDELKWGAKEVEDHYCDACQFSNRFPRYNNPEKLLETRCGRCGEWANCFTLCCRAVGFEARYVWDYTDHVWTEVYSPSQQRWLHCDACEDVCDKPLLYEIGWGKKLSYVIAFSKDEVVDVTWRYSCKHEEVIARRTKVKEALLRDTINGLNKQRQLFLSENRRKELLQRIIVELVEFISPKTPKPGELGGRISGSVAWRVARGEMGLQRKETLFIPCENEKISKQLHLCYNIVKDRYVRVSNNNQTISGWENGVWKMESIFRKVETDWHMVYLARKEGSSFAYISWKFECGSVGLKVDSISIRTSSQTFQTGTVEWKLRSDTAQVELTGDNSLHSYADFSGATEVILEAELSRGDGDVAWQHTQLFRQSLNDHEENCLEIIIKFSDL
  
Inhibitor
Name:
BDBM36388
Synonyms:
BDBM36404 | CID54445 | Octahydro-indolizine-1,6,7,8-tetraol, 13
Type:
Small organic molecule
Emp. Form.:
C8H15NO4
Mol. Mass.:
189.209
SMILES:
O[C@H]1CCN2C[C@H](O)[C@@H](O)[C@H](O)[C@@H]12
Structure:
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