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Target
Matrilysin
Ligand
BDBM50095568
Substrate
n/a
Meas. Tech.
ChEMBL_105032 (CHEMBL711546)
IC50
4200±n/a nM
Citation
 Natchus, MG; Bookland, RG; De, B; Almstead, NG; Pikul, S; Janusz, MJ; Heitmeyer, SA; Hookfin, EB; Hsieh, LC; Dowty, ME; Dietsch, CR; Patel, VS; Garver, SM; Gu, F; Pokross, ME; Mieling, GE; Baker, TR; Foltz, DJ; Peng, SX; Bornes, DM; Strojnowski, MJ; Taiwo, YO Development of new hydroxamate matrix metalloproteinase inhibitors derived from functionalized 4-aminoprolines. J Med Chem 43:4948-63 (2001) [PubMed]
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50095568
Synonyms:
1-(4-Butoxy-benzenesulfonyl)-4-(2-hydroxy-propionylamino)-pyrrolidine-2-carboxylic acid hydroxyamide | CHEMBL356520
Type:
Small organic molecule
Emp. Form.:
C18H27N3O7S
Mol. Mass.:
429.488
SMILES:
CCCCOc1ccc(cc1)S(=O)(=O)N1C[C@H](C[C@@H]1C(=O)NO)NC(=O)[C@H](C)O
Structure:
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