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Target
Cyclin-dependent kinase 6
Ligand
BDBM50539904
Substrate
n/a
Meas. Tech.
ChEMBL_1979639 (CHEMBL4612774)
IC50
>10000±n/a nM
Citation
 Liu, Y; Hao, M; Leggett, AL; Gao, Y; Ficarro, SB; Che, J; He, Z; Olson, CM; Marto, JA; Kwiatkowski, NP; Zhang, T; Gray, NS Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13. J Med Chem 63:6708-6726 (2020) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 6
Synonyms:
CDK6 | CDK6_HUMAN | CDKN6 | Cell division protein kinase 6 | Cyclin-dependent kinase 6 (CDK 6) | Serine/threonine-protein kinase PLSTIRE
Type:
Enzyme Subunit
Mol. Mass.:
36937.42
Organism:
Homo sapiens (Human)
Description:
Q00534
Residue:
326
Sequence:
MEKDGLCRADQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTGEEGMPLSTIREVAVLRHLETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHVDQDLTTYLDKVPEPGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARIYSFQMALTSVVVTLWYRAPEVLLQSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRDVALPRQAFHSKSAQPIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPYFQDLERCKENLDSHLPPSQNTSELNTA
  
Inhibitor
Name:
BDBM50539904
Synonyms:
CHEMBL4647764
Type:
Small organic molecule
Emp. Form.:
C26H31N5O3S2
Mol. Mass.:
525.686
SMILES:
CC(C)(C)c1cnc(CSc2cnc(N[C@@H]3CCCN(C3)C(=O)c3ccc(NC(=O)C=C)cc3)s2)o1 |r|
Structure:
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