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Target
Alpha-2C adrenergic receptor
Ligand
BDBM160473
Substrate
n/a
Meas. Tech.
ChEMBL_1981488 (CHEMBL4614750)
IC50
>30000±n/a nM
Citation
 Mainolfi, N; Ehara, T; Karki, RG; Anderson, K; Mac Sweeney, A; Liao, SM; Argikar, UA; Jendza, K; Zhang, C; Powers, J; Klosowski, DW; Crowley, M; Kawanami, T; Ding, J; April, M; Forster, C; Serrano-Wu, M; Capparelli, M; Ramqaj, R; Solovay, C; Cumin, F; Smith, TM; Ferrara, L; Lee, W; Long, D; Prentiss, M; De Erkenez, A; Yang, L; Liu, F; Sellner, H; Sirockin, F; Valeur, E; Erbel, P; Ostermeier, D; Ramage, P; Gerhartz, B; Schubart, A; Flohr, S; Gradoux, N; Feifel, R; Vogg, B; Wiesmann, C; Maibaum, J; Eder, J; Sedrani, R; Harrison, RA; Mogi, M; Jaffee, BD; Adams, CM Discovery of 4-((2 S,4 S)-4-Ethoxy-1-((5-methoxy-7-methyl-1 H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases J Med Chem 63:5697-5722 (2020) [PubMed]  Article
Target
Name:
Alpha-2C adrenergic receptor
Synonyms:
ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:
Enzyme
Mol. Mass.:
49552.32
Organism:
Homo sapiens (Human)
Description:
P18825
Residue:
462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
  
Inhibitor
Name:
BDBM160473
Synonyms:
US10093663, Example 25b | US9682968, Example-25a (+)
Type:
Small organic molecule
Emp. Form.:
C23H26N2O2
Mol. Mass.:
362.4647
SMILES:
Cc1cc(C)c2[nH]ccc2c1CN1CCCCC1c1ccc(cc1)C(O)=O
Structure:
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