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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50097976
Substrate
n/a
Meas. Tech.
ChEBML_90526
IC50
>5000±n/a nM
Citation
 Altmann, E; Missbach, M; Green, J; Susa, M; Wagenknecht, HA; Widler, L 7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src. Bioorg Med Chem Lett 11:853-6 (2001) [PubMed]
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Proto-oncogene c-Src | SRC | SRC_CHICK | Tyrosine-protein kinase SRC | c-Src | p60-Src | p60c-src | pp60c-src
Type:
Tyr protein kinase
Mol. Mass.:
60015.36
Organism:
Gallus gallus (Chicken)
Description:
P00523
Residue:
533
Sequence:
MGSSKSKPKDPSQRRRSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50097976
Synonyms:
CHEMBL352829 | [(R)-4-((S)-4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-pyrrolidin-2-yl]-acetic acid ethyl ester
Type:
Small organic molecule
Emp. Form.:
C20H23N5O2
Mol. Mass.:
365.4289
SMILES:
CCOC(=O)C[C@H]1C[C@H](CN1)n1cc(-c2ccccc2)c2c(N)ncnc12
Structure:
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