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Target
Histone deacetylase 3
Ligand
BDBM50542698
Substrate
n/a
Meas. Tech.
ChEMBL_1987693 (CHEMBL4621240)
IC50
>100000±n/a nM
Citation
 Konstantinovi?, J; Yahiaoui, S; Alhayek, A; Haupenthal, J; Schönauer, E; Andreas, A; Kany, AM; Müller, R; Koehnke, J; Berger, FK; Bischoff, M; Hartmann, RW; Brandstetter, H; Hirsch, AKH -Aryl-3-mercaptosuccinimides as Antivirulence Agents Targeting  J Med Chem 63:8359-8368 (2020) [PubMed]  Article
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50542698
Synonyms:
CHEMBL4636059
Type:
Small organic molecule
Emp. Form.:
C12H11NO3S
Mol. Mass.:
249.286
SMILES:
CC(=O)c1ccc(cc1)N1C(=O)CC(S)C1=O
Structure:
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