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Target
Histone deacetylase 8
Ligand
BDBM50544215
Substrate
n/a
Meas. Tech.
ChEMBL_1992070 (CHEMBL4625805)
IC50
16±n/a nM
Citation
 Liu, J; Kelly, J; Yu, W; Clausen, D; Yu, Y; Kim, H; Duffy, JL; Chung, CC; Myers, RW; Carroll, S; Klein, DJ; Fells, J; Holloway, MK; Wu, J; Wu, G; Howell, BJ; Barnard, RJO; Kozlowski, JA Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance. ACS Med Chem Lett 11:1476-1483 (2020) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50544215
Synonyms:
CHEMBL4637689
Type:
Small organic molecule
Emp. Form.:
C25H30FN5O3
Mol. Mass.:
467.5358
SMILES:
CN1CC(C1)C(=O)N[C@@H](CCCCCC(=O)c1cc(C)on1)c1ncc([nH]1)-c1ccccc1F |r|
Structure:
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