Reaction Details  Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50545404
Substrate
n/a
Meas. Tech.
ChEMBL_1995015 (CHEMBL4628910)
EC50
4700±n/a nM
Citation
 Dorich, S; Cox, JH; Burch, JD; Chagnon, F; Chen, B; Léger, S; St-Onge, M; Fader, LD Novel pyridone EP Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50545404
Synonyms:
CHEMBL4633041
Type:
Small organic molecule
Emp. Form.:
C23H27Cl2NO4
Mol. Mass.:
452.371
SMILES:
CCCCCC(C)(O)\C=C\c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(cc1)C(O)=O
Structure:
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