Reaction Details  Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50545404
Substrate
n/a
Meas. Tech.
ChEMBL_1995016 (CHEMBL4628911)
EC50
>10000±n/a nM
Citation
 Dorich, S; Cox, JH; Burch, JD; Chagnon, F; Chen, B; Léger, S; St-Onge, M; Fader, LD Novel pyridone EP Bioorg Med Chem Lett 30:0 (2020) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50545404
Synonyms:
CHEMBL4633041
Type:
Small organic molecule
Emp. Form.:
C23H27Cl2NO4
Mol. Mass.:
452.371
SMILES:
CCCCCC(C)(O)\C=C\c1c(Cl)cc(Cl)c(=O)n1CCc1ccc(cc1)C(O)=O
Structure:
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