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Target
5-hydroxytryptamine receptor 7
Ligand
BDBM50545435
Substrate
n/a
Meas. Tech.
ChEMBL_1995295 (CHEMBL4629190)
Ki
9.0±n/a nM
Citation
 Zar?ba, P; Drabczyk, AK; Ja?kowska, J; Sata?a, G Chemical puzzles in the search for new, flexible derivatives of lurasidone as antipsychotic drugs. Bioorg Med Chem 28:0 (2020) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 7
Synonyms:
5-HT-7 | 5-HT-X | 5-HT7 | 5-HT7L | 5-HT7S | 5-HT7b | 5HT7 | 5HT7R_HUMAN | HTR7 | Serotonin receptor 7
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
53573.08
Organism:
Homo sapiens (Human)
Description:
P34969
Residue:
479
Sequence:
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
  
Inhibitor
Name:
BDBM50545435
Synonyms:
CHEMBL4641609
Type:
Small organic molecule
Emp. Form.:
C26H34N4O2S
Mol. Mass.:
466.639
SMILES:
[H][C@]12CC[C@]([H])(C1)[C@]1([H])C(=O)N(CCCCCCN3CCN(CC3)c3nsc4ccccc34)C(=O)[C@]21[H] |r|
Structure:
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