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Target
Retinoic acid receptor RXR-alpha
Ligand
BDBM18862
Substrate
n/a
Meas. Tech.
ChEMBL_1995681 (CHEMBL4629576)
EC50
12000±n/a nM
Citation
 Gellrich, L; Heitel, P; Heering, J; Kilu, W; Pollinger, J; Goebel, T; Kahnt, A; Arifi, S; Pogoda, W; Paulke, A; Steinhilber, D; Proschak, E; Wurglics, M; Schubert-Zsilavecz, M; Chaikuad, A; Knapp, S; Bischoff, I; Fürst, R; Merk, D l-Thyroxin and the Nonclassical Thyroid Hormone TETRAC Are Potent Activators of PPAR?. J Med Chem 63:6727-6740 (2020) [PubMed]  Article
Target
Name:
Retinoic acid receptor RXR-alpha
Synonyms:
NR2B1 | Nuclear receptor subfamily 2 group B member 1 | Nuclear receptor subfamily 4 group A member 2 | Nuclear receptor subfamily 4 group A member 2/Retinoic acid receptor RXR-alpha | RXRA | RXRA_HUMAN | Retinoic acid receptor RXR-alpha/gamma | Retinoid X receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50820.38
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1456363
Residue:
462
Sequence:
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
  
Inhibitor
Name:
BDBM18862
Synonyms:
2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid | CHEMBL41632 | TRIAC | Tiratricol | Triiodothyroacetic acid, 3 | US10322118, Entry Tiratricol
Type:
Small organic molecule
Emp. Form.:
C14H9I3O4
Mol. Mass.:
621.9323
SMILES:
OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1
Structure:
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