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Target
Prothrombin
Ligand
BDBM50106068
Substrate
n/a
Meas. Tech.
ChEBML_208873
IC50
>10000±n/a nM
Citation
Su, T; Wu, Y; Doughan, B; Jia, ZJ; Woolfrey, J; Huang, B; Wong, P; Park, G; Sinha, U; Scarborough, RM; Zhu, BY Design, synthesis, and SAR of amino acid derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 11:2947-50 (2001) [PubMed]
More Info.:
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Inhibitor
Name:
BDBM50106068
Synonyms:
(S)-2-(1-Amino-isoquinoline-7-carbonyl)-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid (2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL100013
Type:
Small organic molecule
Emp. Form.:
C32H27N5O4S
Mol. Mass.:
577.653
SMILES:
Nc1nccc2ccc(cc12)C(=O)N1Cc2ccccc2C[C@H]1C(=O)Nc1ccc(cc1)-c1ccccc1S(N)(=O)=O