Reaction Details 
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D(2) dopamine receptor
Ligand
BDBM50546857
Substrate
n/a
Meas. Tech.
ChEMBL_2016821 (CHEMBL4670399)
Ki
<1000±n/a nM
Citation
Sniecikowska, J; Gluch-Lutwin, M; Bucki, A; Wi?ckowska, A; Siwek, A; Jastrzebska-Wiesek, M; Partyka, A; Wilczy?ska, D; Pytka, K; Latacz, G; Przejczowska-Pomierny, K; Wyska, E; Weso?owska, A; Paw?owski, M; Newman-Tancredi, A; Kolaczkowski, M Discovery of Novel pERK1/2- or ?-Arrestin-Preferring 5-HT J Med Chem 63:10946-10971 (2020) [PubMed] ArticleMore Info.:
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
Inhibitor
Name:
BDBM50546857
Synonyms:
CHEMBL4757755
Type:
Small organic molecule
Emp. Form.:
C23H26ClF2N3O2
Mol. Mass.:
449.921
SMILES:
Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2cccc3NCCc23)CC1
Structure:
