Reaction Details 
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5-hydroxytryptamine receptor 1A
Ligand
BDBM433474
Substrate
n/a
Meas. Tech.
ChEMBL_2016831 (CHEMBL4670409)
EC50
63±n/a nM
Citation
Sniecikowska, J; Gluch-Lutwin, M; Bucki, A; Wi?ckowska, A; Siwek, A; Jastrzebska-Wiesek, M; Partyka, A; Wilczy?ska, D; Pytka, K; Latacz, G; Przejczowska-Pomierny, K; Wyska, E; Weso?owska, A; Paw?owski, M; Newman-Tancredi, A; Kolaczkowski, M Discovery of Novel pERK1/2- or ?-Arrestin-Preferring 5-HT J Med Chem 63:10946-10971 (2020) [PubMed] ArticleMore Info.:
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
Inhibitor
Name:
BDBM433474
Synonyms:
US10562853, Compound 1
Type:
Small organic molecule
Emp. Form.:
C21H23ClF2N2O2
Mol. Mass.:
408.869
SMILES:
Fc1ccc(cc1Cl)C(=O)N1CCC(F)(CNCCOc2ccccc2)CC1
Structure:
