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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM80759
Substrate
n/a
Meas. Tech.
ChEMBL_154455 (CHEMBL756368)
IC50
>100000±n/a nM
Citation
 Lazo, JS; Aslan, DC; Southwick, EC; Cooley, KA; Ducruet, AP; Joo, B; Vogt, A; Wipf, P Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25. J Med Chem 44:4042-9 (2001) [PubMed]
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM80759
Synonyms:
7-[(1-hydroxy-1-phenylpropan-2-yl)amino]quinoline-5,8-dione | 7-[(1-oxidanyl-1-phenyl-propan-2-yl)amino]quinoline-5,8-dione | 7-[(2-hydroxy-1-methyl-2-phenyl-ethyl)amino]quinoline-5,8-quinone | CHEMBL339439 | MLS002702297 | SMR001565859 | cid_386231
Type:
Small organic molecule
Emp. Form.:
C18H16N2O3
Mol. Mass.:
308.3312
SMILES:
CC(Nc1cc(O)c2cccnc2c1O)C(=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: