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Target
Histone deacetylase 8
Ligand
BDBM50252392
Substrate
n/a
Meas. Tech.
ChEMBL_2020076 (CHEMBL4673889)
IC50
1000±n/a nM
Citation
 Wang, XX; Wan, RZ; Liu, ZP Recent advances in the discovery of potent and selective HDAC6 inhibitors. Eur J Med Chem 143:1406-1418 (2018) [PubMed]  Article
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM50252392
Synonyms:
CHEMBL4069287
Type:
Small organic molecule
Emp. Form.:
C18H16N2O4S
Mol. Mass.:
356.396
SMILES:
ONC(=O)c1ccc(Cn2c3CCS(=O)(=O)c3c3ccccc23)cc1
Structure:
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