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Target
Delta-type opioid receptor
Ligand
BDBM50451441
Substrate
n/a
Meas. Tech.
ChEMBL_146921 (CHEMBL757313)
Ki
2.4±n/a nM
Citation
 Yu, H; Prisinzano, T; Dersch, CM; Marcus, J; Rothman, RB; Jacobson, AE; Rice, KC Synthesis and biological activity of 8beta-substituted hydrocodone indole and hydromorphone indole derivatives. Bioorg Med Chem Lett 12:165-8 (2001) [PubMed]
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50451441
Synonyms:
CHEMBL607396
Type:
Small organic molecule
Emp. Form.:
C23H22N2O2
Mol. Mass.:
358.433
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(C)CC[C@@]14[C@@]5([H])Cc1c2[nH]c2ccccc12)ccc3O |r,THB:10:9:4.5.6:14|
Structure:
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