Reaction Details  Report a problem with these data
Target
Protein kinase C delta type
Ligand
BDBM50096601
Substrate
n/a
Meas. Tech.
ChEMBL_161472 (CHEMBL770275)
Ki
35.1±n/a nM
Citation
 Rong, SB; Enyedy, IJ; Qiao, L; Zhao, L; Ma, D; Pearce, LL; Lorenzo, PS; Stone, JC; Blumberg, PM; Wang, S; Kozikowski, AP Structural basis of RasGRP binding to high-affinity PKC ligands. J Med Chem 45:853-60 (2002) [PubMed]
Target
Name:
Protein kinase C delta type
Synonyms:
KPCD_MOUSE | Pkcd | Prkcd | Protein kinase C delta | Protein kinase C delta type | nPKC-delta
Type:
PROTEIN
Mol. Mass.:
77554.99
Organism:
Mus musculus
Description:
ChEMBL_1351519
Residue:
674
Sequence:
MAPFLRISFNSYELGSLQVEDEASQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKTTFDAHIYEGRVIQIVLMRAAEDPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMCVQYFLEDGDCKQSMRSEEEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRSSRKLDTTESVGIYQGFEKKPEVSGSDILDNNGTYGKIWEGSTRCTLENFTFQKVLGKGSFGKVLLAELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLGVTGNIRIHPFFKTINWSLLEKRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFVNPKFEQFLDI
  
Inhibitor
Name:
BDBM50096601
Synonyms:
(2S,5S)-8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-7-methoxy-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one | 8-Dec-1-ynyl-5-hydroxymethyl-2-isopropyl-7-methoxy-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4]diazocin-3-one | CHEMBL7078
Type:
Small organic molecule
Emp. Form.:
C26H40N2O3
Mol. Mass.:
428.6074
SMILES:
CCCCCCCCC#Cc1ccc2N(C)[C@@H](C(C)C)C(=O)N[C@H](CO)Cc2c1OC
Structure:
Search PDB for entries with ligand similarity: