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Target
Sodium-dependent dopamine transporter
Ligand
BDBM50111894
Substrate
n/a
Meas. Tech.
ChEBML_62179
IC50
401.0±n/a nM
Citation
 Davies, HM; Ren, P; Kong, NX; Sexton, T; Childers, SR Synthesis of iodinated 3beta-aryltropanes with selective binding to either the dopamine or serotonin transporters. Bioorg Med Chem Lett 12:845-7 (2002) [PubMed]
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | Monoamine transporters; Norepininephrine & dopamine | SC6A3_RAT | Slc6a3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT)
Type:
Multi-pass membrane protein
Mol. Mass.:
68749.45
Organism:
Rattus norvegicus (rat)
Description:
P23977
Residue:
619
Sequence:
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
  
Inhibitor
Name:
BDBM50111894
Synonyms:
1-{3-[4-((E)-2-Iodo-propenyl)-phenyl]-8-aza-bicyclo[3.2.1]oct-2-yl}-propan-1-one | CHEMBL423275
Type:
Small organic molecule
Emp. Form.:
C19H24INO
Mol. Mass.:
409.3044
SMILES:
CCC(=O)C1C2CCC(CC1c1ccc(\C=C(/C)I)cc1)N2 |THB:2:4:21:6.7|
Structure:
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