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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50112418
Substrate
n/a
Meas. Tech.
ChEBML_221655
IC50
26±n/a nM
Citation
 Deprez, P; Baholet, I; Burlet, S; Lange, G; Amengual, R; Schoot, B; Vermond, A; Mandine, E; Lesuisse, D Discovery of highly potent Src SH2 binders: structure-activity studies and X-ray structures. Bioorg Med Chem Lett 12:1291-4 (2002) [PubMed]
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50112418
Synonyms:
CHEMBL433046 | Phosphoric acid mono-(4-{2-acetylamino-2-[1-(2'-cyano-biphenyl-4-ylmethyl)-2-oxo-azepan-3-ylcarbamoyl]-ethyl}-phenyl) ester
Type:
Small organic molecule
Emp. Form.:
C31H33N4O7P
Mol. Mass.:
604.5901
SMILES:
CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@H]1CCCCN(Cc2ccc(cc2)-c2ccccc2C#N)C1=O
Structure:
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