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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50558250
Substrate
n/a
Meas. Tech.
ChEMBL_2062458 (CHEMBL4717711)
IC50
39±n/a nM
Citation
 Paul, S; Roy, A; Deka, SJ; Panda, S; Trivedi, V; Manna, D Nitrobenzofurazan derivatives of N'-hydroxyamidines as potent inhibitors of indoleamine-2,3-dioxygenase 1. Eur J Med Chem 121:364-375 (2016) [PubMed]  Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50558250
Synonyms:
CHEMBL4777850
Type:
Small organic molecule
Emp. Form.:
C14H9Cl2N5O4
Mol. Mass.:
382.158
SMILES:
O\N=C(\Cc1ccc(Cl)c(Cl)c1)Nc1ccc([N+]([O-])=O)c2nonc12
Structure:
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