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Target
Tyrosine-protein kinase Fyn
Ligand
BDBM255303
Substrate
n/a
Meas. Tech.
ChEMBL_2071890 (CHEMBL4727424)
IC50
212±n/a nM
Citation
Liu, J; Guiadeen, D; Krikorian, A; Gao, X; Wang, J; Babu Boga, S; Alhassan, AB; Yu, W; Selyutin, O; Yu, Y; Anand, R; Xu, J; Kelly, J; Duffy, JL; Liu, S; Yang, C; Wu, H; Cai, J; Bennett, C; Maloney, KM; Tyagarajan, S; Gao, YD; Fischmann, TO; Presland, J; Mansueto, M; Xu, Z; Leccese, E; Zhang-Hoover, J; Knemeyer, I; Garlisi, CG; Stivers, P; Brandish, PE; Hicks, A; Kim, R; Kozlowski, JA Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes. Bioorg Med Chem Lett 30:0 (2020) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase Fyn
Synonyms:
FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn
Type:
Enzyme
Mol. Mass.:
60762.21
Organism:
Homo sapiens (Human)
Description:
P06241
Residue:
537
Sequence:
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQGLTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCCRLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL