Reaction Details  Report a problem with these data
Target
Protein arginine N-methyltransferase 5
Ligand
BDBM50561818
Substrate
n/a
Meas. Tech.
ChEMBL_2076028 (CHEMBL4731562)
IC50
200±n/a nM
Citation
 Pande, V; Sun, W; Beke, L; Berthelot, D; Brehmer, D; Brown, D; Corbera, J; Irving, S; Meerpoel, L; Nys, T; Parade, M; Robinson, C; Sommen, C; Viellevoye, M; Wu, T; Thuring, JW A Chemical Probe for the Methyl Transferase PRMT5 with a Novel Binding Mode. ACS Med Chem Lett 11:2227-2231 (2020) [PubMed]  Article
Target
Name:
Protein arginine N-methyltransferase 5
Synonyms:
72 kDa ICln-binding protein | ANM5_HUMAN | HRMT1L5 | Histone-arginine N-methyltransferase PRMT5 | IBP72 | JBP1 | Jak-binding protein 1 | PRMT5 | PRMT5/MEP50 complex | Protein arginine N-methyltransferase 5 (PRMT5) | Protein arginine methyltransferase 5 (PRMT5) | SKB1 | SKB1 homolog | SKB1Hs | Shk1 kinase-binding protein 1 homolog
Type:
Enzyme
Mol. Mass.:
72679.99
Organism:
Homo sapiens (Human)
Description:
O14744
Residue:
637
Sequence:
MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
  
Inhibitor
Name:
BDBM50561818
Synonyms:
CHEMBL4783377
Type:
Small organic molecule
Emp. Form.:
C20H30N6O3
Mol. Mass.:
402.4906
SMILES:
CN1CCC2(CCCN2C[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2ccc3c(N)ncnc23)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: