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Target
Histamine H1 receptor
Ligand
BDBM50562550
Substrate
n/a
Meas. Tech.
ChEMBL_2079132 (CHEMBL4734923)
Ki
4574±n/a nM
Citation
 Szczepa?ska, K; Pockes, S; Podlewska, S; Höring, C; Mika, K; Latacz, G; Bednarski, M; Siwek, A; Karcz, T; Nagl, M; Bresinsky, M; Mönnich, D; Seibel, U; Kuder, KJ; Kota?ska, M; Stark, H; Elz, S; Kie?-Kononowicz, K Structural modifications in the distal, regulatory region of histamine H Eur J Med Chem 213:0 (2021) [PubMed]  Article
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50562550
Synonyms:
CHEMBL4800672
Type:
Small organic molecule
Emp. Form.:
C24H27N3O2
Mol. Mass.:
389.4901
SMILES:
C(COc1ccc(Oc2ccccc2)cc1)CN1CCN(CC1)c1ccncc1
Structure:
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