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Target
Histamine H4 receptor
Ligand
BDBM50562549
Substrate
n/a
Meas. Tech.
ChEMBL_2079134 (CHEMBL4734925)
Ki
>10000±n/a nM
Citation
 Szczepa?ska, K; Pockes, S; Podlewska, S; Höring, C; Mika, K; Latacz, G; Bednarski, M; Siwek, A; Karcz, T; Nagl, M; Bresinsky, M; Mönnich, D; Seibel, U; Kuder, KJ; Kota?ska, M; Stark, H; Elz, S; Kie?-Kononowicz, K Structural modifications in the distal, regulatory region of histamine H Eur J Med Chem 213:0 (2021) [PubMed]  Article
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50562549
Synonyms:
CHEMBL4786308
Type:
Small organic molecule
Emp. Form.:
C25H29N3O
Mol. Mass.:
387.5173
SMILES:
C(COc1ccc(Cc2ccccc2)cc1)CN1CCN(CC1)c1ccncc1
Structure:
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