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Target
Cyclin-dependent kinase 2
Ligand
BDBM50563140
Substrate
n/a
Meas. Tech.
ChEMBL_2081666 (CHEMBL4737457)
Kd
5000±n/a nM
Citation
 Lee, JC; Hong, KH; Becker, A; Tash, JS; Schönbrunn, E; Georg, GI Tetrahydroindazole inhibitors of CDK2/cyclin complexes. Eur J Med Chem 214:0 (2021) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 2
Synonyms:
CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
33938.17
Organism:
Homo sapiens (Human)
Description:
P24941
Residue:
298
Sequence:
MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
  
Inhibitor
Name:
BDBM50563140
Synonyms:
CHEMBL1906448
Type:
Small organic molecule
Emp. Form.:
C15H16BrN3O
Mol. Mass.:
334.211
SMILES:
Cc1nn(c2C(Br)C(C)(C)CC(=O)c12)-c1ccccn1
Structure:
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