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Target
DNA repair protein RAD52 homolog
Ligand
BDBM50565809
Substrate
n/a
Meas. Tech.
ChEMBL_2093902 (CHEMBL4775165)
IC50
5000±n/a nM
Citation
 Myers, SH; Ortega, JA; Cavalli, A Synthetic Lethality through the Lens of Medicinal Chemistry. J Med Chem 63:14151-14183 (2020) [PubMed]  Article
Target
Name:
DNA repair protein RAD52 homolog
Synonyms:
DNA repair protein RAD52 homolog | RAD52 | RAD52_HUMAN
Type:
PROTEIN
Mol. Mass.:
46177.71
Organism:
Human
Description:
ChEMBL_105690
Residue:
418
Sequence:
MSGTEEAILGGRDSHPAAGGGSVLCFGQCQYTAEEYQAIQKALRQRLGPEYISSRMAGGGQKVCYIEGHRVINLANEMFGYNGWAHSITQQNVDFVDLNNGKFYVGVCAFVRVQLKDGSYHEDVGYGVSEGLKSKALSLEKARKEAVTDGLKRALRSFGNALGNCILDKDYLRSLNKLPRQLPLEVDLTKAKRQDLEPSVEEARYNSCRPNMALGHPQLQQVTSPSRPSHAVIPADQDCSSRSLSSSAVESEATHQRKLRQKQLQQQFRERMEKQQVRVSTPSAEKSEAAPPAPPVTHSTPVTVSEPLLEKDFLAGVTQELIKTLEDNSEKWAVTPDAGDGVVKPSSRADPAQTSDTLALNNQMVTQNRTPHSVCHQKPQAKSGSWDLQTYSADQRTTGNWESHRKSQDMKKRKYDPS
  
Inhibitor
Name:
BDBM50565809
Synonyms:
CHEMBL1718911
Type:
Small organic molecule
Emp. Form.:
C23H36N6S
Mol. Mass.:
428.637
SMILES:
CCN(CC)CCN=C(S)Nc1ccc2nc(cc(C)c2c1)N1CCN(CC)CC1
Structure:
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