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Target
Dual specificity protein kinase CLK2
Ligand
BDBM50568997
Substrate
n/a
Meas. Tech.
ChEMBL_2107268 (CHEMBL4815943)
IC50
50±n/a nM
Citation
 Zhang, Y; Xia, A; Zhang, S; Lin, G; Liu, J; Chen, P; Mu, B; Jiao, Y; Xu, W; Chen, M; Li, L Discovery of 3,6-disubstutited-imidazo[1,2-a]pyridine derivatives as a new class of CLK1 inhibitors. Bioorg Med Chem Lett 41:0 (2021) [PubMed]  Article
Target
Name:
Dual specificity protein kinase CLK2
Synonyms:
2.7.12.1 | CDC-like kinase 2 | CDC-like kinase 2 (CLK2) | CDC2-like kinase 2 (CLK2) | CLK2 | CLK2_HUMAN
Type:
n/a
Mol. Mass.:
60128.79
Organism:
Homo sapiens (Human)
Description:
P49760
Residue:
499
Sequence:
MPHPRRYHSSERGSRGSYREHYRSRKHKRRRSRSWSSSSDRTRRRRREDSYHVRSRSSYDDRSSDRRVYDRRYCGSYRRNDYSRDRGDAYYDTDYRHSYEYQRENSSYRSQRSSRRKHRRRRRRSRTFSRSSSQHSSRRAKSVEDDAEGHLIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHRRGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLSTFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRDERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFTLFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTSEAEEHHQLFDLIESMLEYEPAKRLTLGEALQHPFFARLRAEPPNKLWDSSRDISR
  
Inhibitor
Name:
BDBM50568997
Synonyms:
CHEMBL4853178
Type:
Small organic molecule
Emp. Form.:
C25H20N4O2
Mol. Mass.:
408.4519
SMILES:
COc1ccc(CNC(=O)c2cnc3ccc(cn23)-c2ccc3ncccc3c2)cc1
Structure:
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