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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50571039
Substrate
n/a
Meas. Tech.
ChEMBL_2113641 (CHEMBL4822491)
IC50
27±n/a nM
Citation
 Qiu, H; Ali, Z; Bender, A; Caldwell, R; Chen, YY; Fang, Z; Gardberg, A; Glaser, N; Goettsche, A; Goutopoulos, A; Grenningloh, R; Hanschke, B; Head, J; Johnson, T; Jones, C; Jones, R; Kulkarni, S; Maurer, C; Morandi, F; Neagu, C; Poetzsch, S; Potnick, J; Schmidt, R; Roe, K; Viacava Follis, A; Wing, C; Zhu, X; Sherer, B Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors. Bioorg Med Chem 40:0 (2021) [PubMed]  Article
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Calmodulin/Proto-oncogene tyrosine-protein kinase Src | Protein cereblon/Tyrosine-protein kinase SRC | Proto-oncogene c-Src | Proto-oncogene tyrosine-protein kinase Src (c-Src) | SRC | SRC1 | SRC_HUMAN | Tyrosine-protein kinase Src (SRC) | V-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | c-Src | p60-Src | pp60c-src
Type:
Protein
Mol. Mass.:
59838.60
Organism:
Homo sapiens (Human)
Description:
P12931
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50571039
Synonyms:
CHEMBL4877846
Type:
Small organic molecule
Emp. Form.:
C32H38N8O2
Mol. Mass.:
566.6965
SMILES:
CC(C)n1nc(C)c(c1C)-c1nc2c(ccnc2[nH]1)-c1ccc2[C@@H](CCCCc2c1)NC(=O)c1nc(no1)C(C)(C)C |r|
Structure:
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