Reaction Details Report a problem with these data
Target
Tyrosine-protein kinase
Ligand
BDBM50571039
Substrate
n/a
Meas. Tech.
ChEMBL_2113647 (CHEMBL4822497)
IC50
11±n/a nM
Citation
Qiu, H; Ali, Z; Bender, A; Caldwell, R; Chen, YY; Fang, Z; Gardberg, A; Glaser, N; Goettsche, A; Goutopoulos, A; Grenningloh, R; Hanschke, B; Head, J; Johnson, T; Jones, C; Jones, R; Kulkarni, S; Maurer, C; Morandi, F; Neagu, C; Poetzsch, S; Potnick, J; Schmidt, R; Roe, K; Viacava Follis, A; Wing, C; Zhu, X; Sherer, B Discovery of potent and selective reversible Bruton's tyrosine kinase inhibitors. Bioorg Med Chem 40:0 (2021) [PubMed] Article
More Info.:
Target
Name:
Tyrosine-protein kinase
Synonyms:
2.7.10.2 | Btk | Tyrosine-protein kinase
Type:
PROTEIN
Mol. Mass.:
76412.09
Organism:
Rattus norvegicus
Description:
ChEMBL_120432
Residue:
660
Sequence:
MAAVILESIFLKRSQQKKKTSPLNFKKRLFLLTVHKLSYYEYDFERGRRGSKKGSIDVEKITCVETVVPEKNPPPERQIPVPRGEESSEMEQISIIERFPYPFQVVYDEGPLYVFSPTEELRKRWIHQLKNVIRYNSDLVQKYHPCFWIDGQYLCCSQTAKNAMGCQILENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPEPTAAPISTSELKKVVALYDYMPMNANDLQLRKGEEYFILEESNLPWWRARDKNGQEGYIPSNYVTEAEDSIEMYEWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQYYLAEKHLFSTIPELINYHQHNSAGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIREGSMSEDEFIEEAKVMMNLSHEKLVQLYGVCTKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSLGKIPYERFTNSETAEHIAQGLRLYRPHLASDRVYTIMYSCWHEKADERPSFKILLSNILDVMDEES