Reaction Details  Report a problem with these data
Target
MAP kinase-interacting serine/threonine-protein kinase 1
Ligand
BDBM50130693
Substrate
n/a
Meas. Tech.
ChEMBL_2119185 (CHEMBL4828251)
IC50
870±n/a nM
Citation
 Han, Y; Zhang, H; Wang, S; Li, B; Xing, K; Shi, Y; Cao, H; Zhang, J; Tong, T; Zang, J; Guan, L; Gao, X; Wang, Y; Liu, D; Huang, M; Jing, Y; Zhao, L Optimization of 4,6-Disubstituted Pyrido[3,2- J Med Chem 64:13719-13735 (2021) [PubMed]  Article
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Synonyms:
MAP Kinase-Interacting Protein Kinase (MNK1) | MAP kinase signal-integrating kinase 1 | MAP kinase-interacting serine/threonine-protein kinase 1 (MnK1) | MAP kinase-interacting serine/threonine-protein kinase MNK1 | MAP-kinase interacting kinase 1 (MNK1) | MAPK signal-integrating kinase 1 | MKNK1 | MKNK1_HUMAN | MNK1
Type:
Serine/threonine-protein kinase
Mol. Mass.:
51342.85
Organism:
Homo sapiens (Human)
Description:
Q9BUB5
Residue:
465
Sequence:
MVSSQKLEKPIEMGSSEPLPIADGDRRRKKKRRGRATDSLPGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSRSRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRDVAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENILCESPEKVSPVKICDFDLGSGMKLNNSCTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEAKDLISKLLVRDAKQRLSAAQVLQHPWVQGQAPEKGLPTPQVLQRNSSTMDLTLFAAEAIALNRQLSQHEENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGEDRSPPTAL
  
Inhibitor
Name:
BDBM50130693
Synonyms:
CGP-57380 | CHEMBL1240885
Type:
Small organic molecule
Emp. Form.:
C11H9FN6
Mol. Mass.:
244.2278
SMILES:
Nc1ncnc2[nH]nc(Nc3ccc(F)cc3)c12
Structure:
Search PDB for entries with ligand similarity: