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Target
RAF proto-oncogene serine/threonine-protein kinase
Ligand
BDBM50139628
Substrate
n/a
Meas. Tech.
ChEBML_163039
IC50
82±n/a nM
Citation
 Khire, UR; Bankston, D; Barbosa, J; Brittelli, DR; Caringal, Y; Carlson, R; Dumas, J; Gane, T; Heald, SL; Hibner, B; Johnson, JS; Katz, ME; Kennure, N; Kingery-Wood, J; Lee, W; Liu, XG; Lowinger, TB; McAlexander, I; Monahan, MK; Natero, R; Renick, J; Riedl, B; Rong, H; Sibley, RN; Smith, RA; Wolanin, D Omega-carboxypyridyl substituted ureas as Raf kinase inhibitors: SAR of the amide substituent. Bioorg Med Chem Lett 14:783-6 (2004) [PubMed]
Target
Name:
RAF proto-oncogene serine/threonine-protein kinase
Synonyms:
C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase RAF | Serine/threonine-protein kinase C-Raf | cRaf
Type:
Serine/threonine-protein kinase
Mol. Mass.:
73082.52
Organism:
Homo sapiens (Human)
Description:
P04049
Residue:
648
Sequence:
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
  
Inhibitor
Name:
BDBM50139628
Synonyms:
3-{4-[3-(4-Chloro-3-trifluoromethyl-phenyl)-ureido]-phenoxy}-N-(2-piperidin-1-yl-ethyl)-benzamide | CHEMBL167894
Type:
Small organic molecule
Emp. Form.:
C28H28ClF3N4O3
Mol. Mass.:
560.995
SMILES:
FC(F)(F)c1cc(NC(=O)Nc2ccc(Oc3cccc(c3)C(=O)NCCN3CCCCC3)cc2)ccc1Cl
Structure:
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