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Target
Proteasome subunit alpha type-1
Ligand
BDBM50577133
Substrate
n/a
Meas. Tech.
ChEMBL_2129501 (CHEMBL4838930)
IC50
>10000±n/a nM
Citation
 Li, X; Hong, D; Zhang, M; Xu, L; Zhou, Y; Li, J; Liu, T Development of peptide epoxyketones as selective immunoproteasome inhibitors. Eur J Med Chem 221:0 (2021) [PubMed]  Article
Target
Name:
Proteasome subunit alpha type-1
Synonyms:
30 kDa prosomal protein | HC2 | Macropain subunit C2 | Multicatalytic endopeptidase complex subunit C2 | NU | PROS-30 | PROS30 | PSA1_HUMAN | PSC2 | PSMA1 | Proteasome component C2 | Proteasome nu chain
Type:
PROTEIN
Mol. Mass.:
29555.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_106197
Residue:
263
Sequence:
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEPMEH
  
Inhibitor
Name:
BDBM50577133
Synonyms:
CHEMBL4870115
Type:
Small organic molecule
Emp. Form.:
C31H40N4O7
Mol. Mass.:
580.6719
SMILES:
CO[C@H]1CCN(C1)C(=O)N[C@H](C)C(=O)N[C@@H](Cc1ccc(OC)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)[C@@]1(C)CO1 |r|
Structure:
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