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Target
Nuclear receptor subfamily 1 group I member 2
Ligand
BDBM50577432
Substrate
n/a
Meas. Tech.
ChEMBL_2130193 (CHEMBL4839622)
EC50
>10000±n/a nM
Citation
 Aicher, TD; Van Huis, CA; Hurd, AR; Skalitzky, DJ; Taylor, CB; Beleh, OM; Glick, G; Toogood, PL; Yang, B; Zheng, T; Huo, C; Gao, J; Qiao, C; Tian, X; Zhang, J; Demock, K; Hao, LY; Lesch, CA; Morgan, RW; Moisan, J; Wang, Y; Scatina, J; Paulos, CM; Zou, W; Carter, LL; Hu, X Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-? (ROR?) Agonist for Use in Treating Cancer. J Med Chem 64:13410-13428 (2021) [PubMed]  Article
Target
Name:
Nuclear receptor subfamily 1 group I member 2
Synonyms:
NR1I2 | NR1I2_HUMAN | Orphan nuclear receptor PAR1 | Orphan nuclear receptor PXR | PXR | Pregnane X receptor | SXR | Steroid and xenobiotic receptor | nuclear receptor subfamily 1 group I member 2 isoform 1
Type:
Nuclear receptor
Mol. Mass.:
49774.77
Organism:
Homo sapiens (Human)
Description:
O75469
Residue:
434
Sequence:
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
  
Inhibitor
Name:
BDBM50577432
Synonyms:
CHEMBL4874647
Type:
Small organic molecule
Emp. Form.:
C24H18ClF4NO5S
Mol. Mass.:
543.915
SMILES:
OC(=O)CC[C@H]1CN(c2cc(ccc2O1)-c1cccc(F)c1Cl)S(=O)(=O)c1cccc(c1)C(F)(F)F |r|
Structure:
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