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Target
Tyrosine-protein kinase receptor UFO
Ligand
BDBM50578078
Substrate
n/a
Meas. Tech.
ChEMBL_2131991 (CHEMBL4841506)
IC50
8960±n/a nM
Citation
 Ng, PS; Foo, K; Sim, S; Wang, G; Huang, C; Tan, LH; Poulsen, A; Liu, B; Tee, DHY; Ahmad, NHB; Wang, S; Ke, Z; Lee, MA; Kwek, ZP; Joy, J; Anantharajan, J; Baburajendran, N; Pendharkar, V; Manoharan, V; Vuddagiri, S; Sangthongpitag, K; Hill, J; Keller, TH; Hung, AW Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors. Bioorg Med Chem 49:0 (2021) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase receptor UFO
Synonyms:
AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN
Type:
Enzyme
Mol. Mass.:
98316.97
Organism:
Homo sapiens (Human)
Description:
P30530
Residue:
894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM50578078
Synonyms:
CHEMBL4860788
Type:
Small organic molecule
Emp. Form.:
C16H19ClN6
Mol. Mass.:
330.815
SMILES:
CN1CC[C@H](C1)Nc1cc2c(n[nH]c2cc1Cl)-c1cnn(C)c1 |r|
Structure:
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