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Target
Histone deacetylase 11
Ligand
BDBM50123628
Substrate
n/a
Meas. Tech.
ChEMBL_2146495 (CHEMBL5030841)
IC50
>10000±n/a nM
Citation
 Zhang, K; Liu, Z; Yao, Y; Qiu, Y; Li, F; Chen, D; Hamilton, DJ; Li, Z; Jiang, S Structure-Based Design of a Selective Class I Histone Deacetylase (HDAC) Near-Infrared (NIR) Probe for Epigenetic Regulation Detection in Triple-Negative Breast Cancer (TNBC). J Med Chem 64:4020-4033 (2021) [PubMed]  Article
Target
Name:
Histone deacetylase 11
Synonyms:
HD11 | HDA11_HUMAN | HDAC11 | Human HDAC11
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
39187.66
Organism:
Homo sapiens (Human)
Description:
Q96DB2
Residue:
347
Sequence:
MLHTTQLYQHVPETRWPIVYSPRYNITFMGLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRYLNELKWSFAVATITEIPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVGGGFHHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGHERDFMDDKRVYIMDVYNRHIYPGDRFAKQAIRRKVELEWGTEDDEYLDKVERNIKKSLQEHLPDVVVYNAGTDILEGDRLGGLSISPAGIVKRDELVFRMVRGRRVPILMVTSGGYQKRTARIIADSILNLFGLGLIGPESPSVSAQNSDTPLLPPAVP
  
Inhibitor
Name:
BDBM50123628
Synonyms:
CHEMBL3622730
Type:
Small organic molecule
Emp. Form.:
C29H42N4O6S2
Mol. Mass.:
606.797
SMILES:
CCCCCCCC(=O)SCC\C=C\[C@@H]1CC(=O)NCc2nc(cs2)C(=O)N\C(=C/C)C(=O)N[C@@H](C(C)C)C(=O)O1 |r|
Structure:
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