Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 5
Ligand
BDBM50148677
Substrate
n/a
Meas. Tech.
ChEBML_39655
IC50
7200±n/a nM
Citation
Shankaran, K; Donnelly, KL; Shah, SK; Caldwell, CG; Chen, P; Finke, PE; Oates, B; MacCoss, M; Mills, SG; DeMartino, JA; Gould, SL; Malkowitz, L; Siciliano, SJ; Springer, MS; Kwei, G; Carella, A; Carver, G; Danzeisen, R; Hazuda, D; Holmes, K; Kessler, J; Lineberger, J; Miller, MD; Emini, EA; Schleif, WA Syntheses and biological evaluation of 5-(piperidin-1-yl)-3-phenyl-pentylsulfones as CCR5 antagonists. Bioorg Med Chem Lett 14:3589-93 (2004) [PubMed] Article
More Info.:
Target
Name:
C-C chemokine receptor type 5
Synonyms:
C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor
Type:
Enzyme
Mol. Mass.:
40540.21
Organism:
Homo sapiens (Human)
Description:
P51681
Residue:
352
Sequence:
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKRLKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFIILLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSSHFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFVGEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
Inhibitor
Name:
BDBM50148677
Synonyms:
Allyl-[1-(5-benzenesulfonyl-3-phenyl-heptyl)-piperidin-4-yl]-carbamic acid 4-nitro-benzyl ester | CHEMBL331754
Type:
Small organic molecule
Emp. Form.:
C35H43N3O6S
Mol. Mass.:
633.797
SMILES:
CCC(CC(CCN1CCC(CC1)N(CC=C)C(=O)OCc1ccc(cc1)[N+]([O-])=O)c1ccccc1)S(=O)(=O)c1ccccc1