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Target
Histone acetyltransferase KAT8
Ligand
BDBM50581154
Substrate
n/a
Meas. Tech.
ChEMBL_2149912 (CHEMBL5034374)
IC50
>100±n/a nM
Citation
 Deng, Y; Deng, S; Ho, YH; Gardner, SM; Huang, Z; Marmorstein, R; Huang, R Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D. J Med Chem 64:8263-8271 (2021) [PubMed]  Article
Target
Name:
Histone acetyltransferase KAT8
Synonyms:
KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF
Type:
PROTEIN
Mol. Mass.:
52413.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796800
Residue:
458
Sequence:
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
  
Inhibitor
Name:
BDBM50581154
Synonyms:
CHEMBL5090533
Type:
Small organic molecule
Emp. Form.:
C34H59N14O21P3S
Mol. Mass.:
1124.9
SMILES:
CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](OP(O)(O)=O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)C(=O)NCCC(=O)NCCSCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O |r|
Structure:
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