Reaction Details  Report a problem with these data
Target
Neuromedin-B receptor
Ligand
BDBM50158698
Substrate
n/a
Meas. Tech.
ChEMBL_306025 (CHEMBL829951)
IC50
1.6±n/a nM
Citation
 Nock, BA; Nikolopoulou, A; Galanis, A; Cordopatis, P; Waser, B; Reubi, JC; Maina, T Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem 48:100-10 (2005) [PubMed]  Article
Target
Name:
Neuromedin-B receptor
Synonyms:
Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43447.11
Organism:
Homo sapiens (Human)
Description:
Bombesin 1 NMBR 0::P28336
Residue:
390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
  
Inhibitor
Name:
BDBM50158698
Synonyms:
CHEMBL266078 | [N40,Pro1,Tyr4]BB
Type:
Small organic molecule
Emp. Form.:
C83H130N28O19S
Mol. Mass.:
1856.162
SMILES:
CSCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CNCCN)CNCCN)C(C)C)C(N)=O
Structure:
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