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Target
Neuromedin-B receptor
Ligand
BDBM50158702
Substrate
n/a
Meas. Tech.
ChEMBL_306025 (CHEMBL829951)
IC50
0.96±n/a nM
Citation
 Nock, BA; Nikolopoulou, A; Galanis, A; Cordopatis, P; Waser, B; Reubi, JC; Maina, T Potent bombesin-like peptides for GRP-receptor targeting of tumors with 99mTc: a preclinical study. J Med Chem 48:100-10 (2005) [PubMed]  Article
Target
Name:
Neuromedin-B receptor
Synonyms:
Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43447.11
Organism:
Homo sapiens (Human)
Description:
Bombesin 1 NMBR 0::P28336
Residue:
390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
  
Inhibitor
Name:
BDBM50158702
Synonyms:
CHEMBL413893 | Universal ligand
Type:
Small organic molecule
Emp. Form.:
C57H76N14O11
Mol. Mass.:
1133.3005
SMILES:
CCCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(C)C)C(N)=O
Structure:
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