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Target
Translocator protein
Ligand
BDBM50159086
Substrate
n/a
Meas. Tech.
ChEMBL_303755 (CHEMBL829798)
Ki
4.269±n/a nM
Citation
 Trapani, G; Laquintana, V; Denora, N; Trapani, A; Lopedota, A; Latrofa, A; Franco, M; Serra, M; Pisu, MG; Floris, I; Sanna, E; Biggio, G; Liso, G Structure-activity relationships and effects on neuroactive steroid synthesis in a series of 2-phenylimidazo[1,2-a]pyridineacetamide peripheral benzodiazepine receptors ligands. J Med Chem 48:292-305 (2005) [PubMed]  Article
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50159086
Synonyms:
8-(2-Chloro-phenyl)-isoquinoline-3-carboxylic acid sec-butyl-methyl-amide | CHEMBL360798
Type:
Small organic molecule
Emp. Form.:
C21H21ClN2O
Mol. Mass.:
352.857
SMILES:
CCC(C)N(C)C(=O)c1cc2cccc(-c3ccccc3Cl)c2cn1
Structure:
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