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Target
Cytochrome c oxidase subunit 2
Ligand
BDBM50589148
Substrate
n/a
Meas. Tech.
ChEMBL_2192004 (CHEMBL5104364)
IC50
1400±n/a nM
Citation
 He, ZX; Gong, YP; Zhang, X; Ma, LY; Zhao, W Pyridazine as a privileged structure: An updated review on anticancer activity of pyridazine containing bioactive molecules. Eur J Med Chem 209:0 (2021) [PubMed]  Article
Target
Name:
Cytochrome c oxidase subunit 2
Synonyms:
COII | COX2 | COX2_HUMAN | COXII | MT-CO2 | MTCO2
Type:
PROTEIN
Mol. Mass.:
25555.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_530099
Residue:
227
Sequence:
MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQEMETVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNSYMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLNQTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL
  
Inhibitor
Name:
BDBM50589148
Synonyms:
CHEMBL5187847
Type:
Small organic molecule
Emp. Form.:
C23H18FN5O3
Mol. Mass.:
431.4191
SMILES:
COc1ccc(cc1)-c1nc(N2N=C(CCC2=O)c2ccc(F)cc2)n(C)c(=O)c1C#N |c:13|
Structure:
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